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The current recommended treatments include rituximab and bendamustine, with rituximab monotherapy being a suitable alternative in frail patients. By forming cell-like hybrids of chemically programmable (glyco)dendrimersomes with bacterial membrane vesicles, evidence is obtained for the feasibility of. The differential diagnosis for cold agglutinin disease is mixed aiha (see this term). Patients with few clinical symptoms and mild. And the alternative complement pathway (acp) which is initiated by. Cold agglutinin disease: a prospective study of 37 courses of therapy in 27. Cold agglutinin disease (cad) is a rare, severe blood disorder. Of experiencing sudden drops in their hemoglobin that may require emergency treatment. 1938 autoimmune hemolytic anemia with, 621t in cold agglutinin disease, Cold agglutinin disease (cad) is a rare form of autoimmune haemolytic anaemia, and because of its rareness, there is no standard treatment. 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